Cells can remain functional despite damage to mitochondria
Mitochondria are the power plants of our cells and play an important role in providing energy for normal function of the tissues in our body. Thanks to a metabolic adjustment, cells can remain functional despite damage to the mitochondria...
Patients’ Diets Need Monitoring for Balance and Levodopa Use, Study Finds
Fewer than 20% of these patients were taking their levodopa medication outside of meals, despite nearly two-thirds being aware that food proteins can affect how this treatment is absorbed by the body.
Investigators advise patients’ eating habits be regularly monitored, and professional guidance be given to improve their diets and better manage their symptoms...
Deep Brain Stimulation Not Linked to Greater Risk of Dementia for Parkinson’s Patients, Study Concludes
Long-term deep brain stimulation (DBS) is cognitively safe and does not increase the risk for dementia in people with Parkinson’s disease, according to the results of a 10-year follow up study.
However, being male, older, having hallucinations, scoring low on cognitive tests, and perioperative cerebral hemorrhage (bleeding in the brain that occurs during or after surgery) were identified as risk factors for developing dementia in Parkinson’s patients with longstanding DBS.
“These results are very encouraging for people with Parkinson’s and their families that they can take advantage of the benefits of deep brain stimulation without worrying about it increasing the likelihood of developing dementia,” Elena Moro, MD, the study’s lead author, said in a press release...
Melatonin Levels in Parkinson’s Patients May Be Linked to Non-motor Symptoms
Melatonin is a hormone produced by the pineal gland, a small pea-shaped gland in the brain that regulates sleep. Higher levels of this hormone are usually present at night...
Rice team makes tiny, magnetically powered neural stimulator
Rice University neuroengineers have created a tiny surgical implant that can electrically stimulate the brain and nervous system without using a battery or wired power supply.
The neural stimulator draws its power from magnetic energy and is about the size of a grain of rice. It is the first magnetically powered neural stimulator that produces the same kind of high-frequency signals as clinically approved, battery-powered implants that are used to treat epilepsy, Parkinson's disease, chronic pain and other conditions...
Parkinson's Patient Improving After First-Ever Stem Cell Therapy
In a first, scientists have treated a Parkinson's disease patient with his own skin cells -- repurposing them to become key brain cells that the disease kills off.
Two years after receiving the experimental treatment, the patient has had no adverse effects, his doctors report. His symptoms, meanwhile, have either stabilized or gotten somewhat better.
"The improvement has been modest," said senior researcher Kwang-Soo Kim, who directs the molecular neurobiology laboratory at the Harvard-affiliated McLean Hospital, in Belmont, Mass...
COVID-19 Presents Distinct Challenges, and Opportunities, with Parkinson’s
People with Parkinson’s disease can face “hidden sorrows” during the COVID-19 pandemic, like increased stress and limits on physical activity, that could worsen their symptoms. But ways exist to mitigate these “less visible” threats of social distancing and other changes in daily routines.
Indeed, the pandemic may facilitate wider access to helpful online resources, and could open new opportunities for research, two neurologists suggest...
Neupro Patches Effective in Parkinson’s, Real-world Study Shows
In a real-world clinical setting, Neupro Patches (rotigotine) eased the clinical signs and symptoms of Parkinson’s disease, with more than 70% of patients reporting mild improvement or better, including those 80 years and older, a real-world study shows.
No new or notable safety concerns were reported...
Deep Brain Stimulation Found Helpful for Working-age Parkinson’s Patients
Working-age adults with Parkinson’s disease who received deep brain stimulation (DBS) showed better social and occupational functioning than those who received the best medical therapies alone, a study has found.
As such, the authors suggest, DBS could be prescribed to this Parkinson’s population to help preserve these aspects of their lives...
DBS Eases Symptoms and May Slow Progression in Early Stage Patients, Study Says
A planned Phase 3 study has already received the go-ahead from the U.S. Food and Drug Administration (FDA). If these results are confirmed in a larger group of earlier stage patients, DBS will be the first therapy shown to be effective at slowing disease progression.
Called “Keep On Moving,” the production also seeks to destigmatize the neurodegenerative disease and show the diversity and accomplishments of people living with Parkinson’s. It’s part of a global campaign that Bial, based in Portugal, launched four years ago...
Foliglurax Fails to Minimize Long-term Use Side Effects of Levodopa, Phase 2 Trial Shows
Despite being safe and well-tolerated, foliglurax (PTX002331), an investigational therapy for Parkinson’s disease, failed to significantly reduce some of the effects associated with long-term use of levodopa, including its “wearing-off” effect and motor complications, according to data from a Phase 2 clinical trial.
As a result, Lundbeck, the company that currently holds the therapy’s development and commercial rights, has decided to terminate its development program and to write-down foliglurax’s current value of €100 million (about $108 million)...
Levodopa Improves Handwriting, Dexterity Tasks in Parkinson’s Patients, Study Indicates
Levodopa improved handwriting and dexterity tasks among people living with Parkinson’s disease, a recent study found.
Neurological examinations of Parkinson’s patients that seek to quantify motor function impairment can vary between different examiners and may make it a struggle to detect subtle changes...
New Insight May Unveil Ways to Lessen Side Effects of Deep Brain Stimulation in Parkinson’s Patients
Distinct connections between nerve cells in the brain may explain why some Parkinson’s disease patients develop impulsivity and behavioral problems after deep brain stimulation (DBS) therapy, according to a recent study.
These findings may help make DBS safer and more effective by adequately targeting the regions in the brain responsible for motor control.
While this device is the fourth deep brain stimulation (DBS) system to be approved in the U.S., it is the first system able to sense and record brain signals while therapy is delivered. As such, it is expected to help doctors more precisely tailor treatment to a patient’s needs.
Link between diesel exhaust and risk of Parkinson’s discovered
Researchers have uncovered the process by which air pollution can damage brain cells, leading to an increased risk of Parkinson’s disease. Chemicals found in diesel fuel reduced autophagic flux, which is a major pathway implicated in neurodegeneration.
A new UCLA study in zebrafish has identified the process by which air pollution can damage brain cells, potentially contributing to Parkinson’s disease.
Published in the peer-reviewed journal Toxicological Sciences, the findings show that chemicals in diesel exhaust can trigger the toxic buildup of a protein in the brain called alpha-synuclein, which is commonly seen in people with the disease...
$70 Million Raised for Neuron Replacement Therapy Techniques to Treat Parkinson’s
The products, ANPD001 and ANPD002, are the first-ever Parkinson’s treatments designed to use a patient’s own cells as a replacement to restore neuronal function and to modify disease progression. This approach is referred to as an autologous neuron replacement therapy...